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Updated: Aug 22, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
[2,5-Bis(di-propyl-amino)-4-(hy-droxy-meth-yl)phen-yl]methanol
Volker Schmitt1, Gideon Holzmann1, Dieter Schollmeyer1
1University of Mainz, Institut for Organic Chemistry, Duesbergweg 10-14, 55099 Mainz, Germany.
Abstract:
The centrosymmetric title compound, C22H36N2O2, was prepared in five steps from diethyl succinate. The di-propyl-amino groups are almost orthogonal to the central phenyl-enedi-methanol ring [dihedral angle = 87.62 (9)°]. In the crystal, the mol-ecules are connected by O-H⋯N hydrogen bonds, forming (101) layers separated by the propyl chains.
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