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Updated: Aug 22, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
(S)-2-[(4-Fluoro-phen-yl)formamido]-3-phenyl-propanoic acid
Kathleen S Lee1, Luke Turner1, Cynthia B Powell1
1Department of Chemistry and Biochemistry, Abilene Christian University, ACU 28132, Abilene, Texas 79699, USA.
Abstract:
The title compound, C16H14FNO3, was synthesized via solid phase methods; it exhibits monoclinic (P21) symmetry at room temperature. The two independent mol-ecules that comprise the asymmetric unit display distinct torsion angles of 173.2 (2) and 72.6 (2)° along the central sp 3 C-N bond. In the crystal, hydrogen bonding through N-H⋯O contacts couples the asymmetric unit mol-ecules into pairs that align in layers extending parallel to (100) via additional O-H⋯O inter-actions. The phenyl ring of one independent mol-ecule was found to be disordered over two sets of sites in a 0.55 (3):0.45 (3) ratio.
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