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Turning Data to Knowledge: Online Tools, Databases, and Resources in microRNA Research
Ido Blass1, Keren Zohar2, Michal Linial3
1The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
Advances in Experimental Medicine and Biology
|November 9, 2022
Summary
This chapter introduces online tools and resources for microRNA (miRNA) research. It highlights their role in cell regulation, disease, and cancer, aiding researchers in navigating miRNA data and understanding its complexity.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression.
- miRNA dysregulation is linked to various diseases, including cancers.
- Understanding miRNA function requires robust computational and experimental tools.
Purpose of the Study:
- To introduce online functional tools and resources for miRNA research.
- To facilitate navigation of miRNA databases and portals.
- To demonstrate the utility of these resources in studying miRNA regulation in health and disease.
Main Methods:
- Computational prediction and experimental monitoring of miRNA-target interactions.
- Utilizing miRNA and mRNA expression databases across human cells and tissues.
- Exploring tools linking miRNAs with transcription factor (TF) networks.
- Reviewing online resources for analyzing miRNAs in human diseases, particularly cancer.
Main Results:
- Online catalogs and gateway portals provide comprehensive miRNA navigation.
- Expression databases reveal miRNA/mRNA alterations in diverse human samples.
- Tools integrating miRNA and TF networks illustrate regulatory complexity.
- Resources for disease-specific miRNA analysis are available.
Conclusions:
- A curated selection of contemporary online resources aids miRNA research.
- These tools are valuable for studying miRNA regulation in cellular processes, health, and disease.
- Facilitating research into miRNA's role in cancer and other pathologies.
