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Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
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Advanced plasmonic technologies for multi-scale biomedical imaging.

Jia-Sheng Lin1, Xiang-Dong Tian1, Gang Li1

  • 1Xiamen Cardiovascular Hospital, State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, College of Energy, Xiamen University, Xiamen 361005, China. wy@medmail.com.cn.

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|November 15, 2022
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Summary
This summary is machine-generated.

Plasmon-based imaging techniques overcome traditional limitations by leveraging light-matter interactions for high-resolution bioimaging. These advanced methods offer unprecedented insights into biological processes at the nanoscale.

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Area of Science:

  • Optics and Photonics
  • Biomedical Imaging
  • Nanotechnology

Background:

  • Traditional imaging modalities lack the spatial resolution required for high-precision biomedical research and diagnostics.
  • Plasmon resonance, a light-matter interaction, enables near-field localization of electromagnetic fields, enhancing nanoscale phenomena.
  • Nanoparticle plasmon resonance scattering is sensitive to local environmental changes, crucial for molecular detection.

Purpose of the Study:

  • To provide a tutorial review of plasmon-based imaging techniques.
  • To discuss the fundamental aspects of plasmonics and their application in bioimaging.
  • To systematically review working principles and achievable spatial resolutions of various plasmon-based techniques.

Main Methods:

  • Surface-enhanced Raman spectroscopy (SERS)
  • Tip-enhanced Raman spectroscopy (TERS)
  • Tip-enhanced fluorescence spectroscopy (TEFS)
  • Scattering-type scanning near-field optical microscopy (s-SNOM)
  • Plasmon/molecular ruler microscopy
  • Tip-enhanced ablation and ionization mass spectrometry

Main Results:

  • Plasmon-based techniques achieve spatial resolutions from micrometers down to the angstrom level.
  • These methods combine spatial resolution with molecular spectrometry (Raman, IR, fluorescence).
  • Applications span from tissue to subcellular levels, interrogating diverse biological processes.

Conclusions:

  • Plasmon-based imaging offers a novel approach to understanding life science mysteries.
  • These techniques hold significant potential for translation from fundamental research to clinical applications.
  • Continued development promises advancements in high-resolution bioimaging and diagnostics.