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A computational roadmap to electronic drugs.

Andreas Rowald1, Oliver Amft1,2,3

  • 1ProModell Group, Chair of Digital Health, Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

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Summary
This summary is machine-generated.

Digital Neuro Twins (DNTs) offer personalized computational tools for optimizing neurostimulation therapies. These DNTs promise to accelerate discovery and improve treatment for neurological disorders.

Keywords:
computational modelingdigital twinsneurological disordersneuromodulationneurostimulationpsychiatric disorders

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Computational Biology

Background:

  • Neurostimulation is a promising alternative to pharmacology for treating neurological and psychiatric disorders.
  • Current neurostimulation strategies advance rapidly, but understanding of underlying mechanisms lags behind clinical application.
  • Therapy design relies heavily on empirical evidence, which is insufficient for optimizing complex, personalized treatments.

Purpose of the Study:

  • To propose Digital Neuro Twins (DNTs) as a solution for optimizing neurostimulation parameters.
  • To highlight the potential of DNTs in accelerating scientific discovery and engineering in neurostimulation.
  • To outline the role of DNTs in supporting clinical and regulatory decision-making for electronic therapies.

Main Methods:

  • Conceptual framework for Digital Neuro Twins (DNTs) development.
  • Emphasis on personalized computational modeling for neurostimulation.
  • Integration of anatomical variability and patient-specific data.

Main Results:

  • DNTs can efficiently explore the multi-dimensional optimization space of neurostimulation.
  • Personalized computational tools are essential for overcoming limitations of empirical research.
  • DNTs facilitate the identification of effective and safe stimulation parameters.

Conclusions:

  • Digital Neuro Twins represent the future of neurostimulation, enabling personalized 'electronic drugs'.
  • DNTs will accelerate the development of broad-application neurostimulation therapies.
  • This approach promises cost-, time-, and risk-efficient therapeutic solutions.