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Updated: Aug 20, 2025

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LUBAC and NF-κB trigger a nuclear response from mitochondria.

Junsheng Chen1, Thomas Simmen1

  • 1Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

The EMBO Journal
|November 18, 2022
PubMed
Summary

Mitochondria are vital for innate immunity. A new study shows the linear ubiquiting chain assembly complex (LUBAC) remodels the outer mitochondrial membrane, aiding NF-κB nuclear transport during TNF signaling.

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