Preoperative Systemic Therapy for Breast Cancer

Area of Science:

• Oncology
• Medical treatment

Background:

• Indications for neoadjuvant systemic therapy in breast cancer have evolved.
• Neoadjuvant therapy is used in both inoperable and operable breast cancer settings.

Purpose of the Study:

• To review current data on neoadjuvant therapy for breast cancer.
• To discuss the evolution of neoadjuvant regimens for specific breast cancer subtypes.
• To examine the role of neoadjuvant chemotherapy in guiding adjuvant treatment decisions.

Main Methods:

• Literature review of current data on neoadjuvant therapy in breast cancer.
• Discussion of neoadjuvant regimens for triple-negative breast cancer.
• Analysis of neoadjuvant approaches for HER2-overexpressing/gene-amplified (HER2+) breast cancer.
• Review of neoadjuvant strategies for hormone receptor-positive breast cancer.

Main Results:

• The use of neoadjuvant therapy in breast cancer has expanded.
• Specific neoadjuvant regimens have shown promise in different breast cancer subtypes.
• Neoadjuvant chemotherapy plays a role in personalizing adjuvant treatment strategies.

Conclusions:

• Neoadjuvant therapy is a dynamic field in breast cancer treatment.
• Understanding neoadjuvant approaches is crucial for optimizing patient outcomes.
• The choice of neoadjuvant treatment is increasingly tailored to tumor biology.