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Updated: Aug 20, 2025

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
Shock in Trauma
1University Hospitals Coventry & Warwickshire NHS Trust, Coventry CV2 2DX, UK; The Air Ambulance Service, Blue Skies House, Butlers Leap, Rugby, Warwickshire, CV21 3RQ. UK.
Abstract:
Shock is a life-threatening condition of circulatory failure leading to inadequate organ perfusion and tissue oxygenation. In a trauma patient, shock may be due to hypovolemia, cardiogenic, obstructive or distributive causes individually or in combination. The physiological response to major hemorrhage is dependent on a variety of autonomic reflexes, mechanism of injury, bleeding source, and baseline physiology of the patient. This article discusses the common causes of shock and the accompanying physiology, how clinical assessment can support the diagnosis and effective treatment of shock, and the common pitfalls in trauma patients.
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