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Detection of Tissue-resident Bacteria in Bladder Biopsies by 16S rRNA Fluorescence In Situ Hybridization
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The Association Between the Urinary Microbiome and Bladder Cancer
Ahmed A Hussein1, Gary Smith1, Khurshid A Guru1
1Department of Urology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Street, Buffalo, NY 14263, USA.
The Urologic Clinics of North America
|November 24, 2022
Summary
Investigating the urinary microbiome in bladder cancer is crucial for identifying biomarkers and therapeutic targets. Understanding these microbial differences can predict treatment response and guide future bladder cancer therapies.
Area of Science:
- Urology
- Microbiology
- Oncology
Background:
- The urinary microbiome's role in bladder cancer is under investigation, with a focus on its association with cancer stages, recurrence, and progression.
- Existing studies are often limited by small sample sizes, confounding factors, and methodological challenges in sampling and analysis.
- There is a growing trend towards analyzing bladder tissue microbiomes, though urine-based studies remain more common.
Purpose of the Study:
- To identify differences in microbiome composition across various bladder cancer stages.
- To explore the potential of these microbial differences as biomarkers for predicting intravesical treatment response.
- To investigate novel therapeutic targets through the modulation of specific bacterial taxa for bladder cancer treatment.
Main Methods:
- Analysis of urinary microbiome composition in patients with bladder cancer.
- Comparison of microbial profiles across different bladder cancer stages.
- Assessment of associations between microbiome characteristics and treatment outcomes.
Main Results:
- Significant differences in urinary microbiome composition are observed between different stages of bladder cancer.
- Specific microbial signatures correlate with the risk of recurrence and progression.
- Potential biomarkers for predicting response to intravesical therapy are identified.
Conclusions:
- Urinary microbiome analysis offers a promising avenue for non-invasive bladder cancer staging and prognosis.
- Microbiome-based biomarkers can aid in personalizing intravesical treatment strategies.
- Targeting specific bacterial taxa within the urinary microbiome presents a novel therapeutic approach for bladder cancer.
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