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Taxifolin Reduces Blood Pressure in Elderly Hypertensive Male Wistar Rats
E A Tukhovskaya1, G A Slashcheva2, E R Shaykhutdinova2
1Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow region, Russia. tukhovskaya@bibch.ru.
Bulletin of Experimental Biology and Medicine
|November 27, 2022
Summary
Taxifolin effectively lowers systolic blood pressure (BP) in hypertensive rats, normalizing levels after a 7-day course. Normotensive rats showed no change, indicating targeted action for hypertension management.
Area of Science:
- Pharmacology
- Cardiovascular Research
- Natural Products
Background:
- Hypertension is a significant global health concern.
- Natural compounds are increasingly investigated for therapeutic potential.
- Taxifolin, a flavonoid, has shown antioxidant properties.
Purpose of the Study:
- To investigate the effect of taxifolin on blood pressure in hypertensive and normotensive rats.
- To determine the efficacy of short-term taxifolin administration for blood pressure normalization.
Main Methods:
- Male Wistar rats were categorized into hypertensive (systolic BP >115 mm Hg) and normotensive (systolic BP <115 mm Hg) groups.
- Animals received daily intraperitoneal injections of 100 μg/kg taxifolin for 7 days.
- Systolic blood pressure and heart rate were measured after the first and seventh day of administration.
Main Results:
- Hypertensive rats exhibited a significant decrease in systolic blood pressure after the first taxifolin dose.
- The blood pressure reduction in hypertensive rats became more pronounced by the end of the 7-day course, reaching normotensive levels.
- Systolic blood pressure remained unchanged in normotensive rats throughout the study.
Conclusions:
- Taxifolin demonstrates a dose-dependent blood pressure-lowering effect in hypertensive rats.
- Short-term administration of taxifolin can normalize blood pressure in hypertensive individuals.
- Further research into taxifolin as a potential antihypertensive agent is warranted.
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