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Published on: February 9, 2011
IgA Vasculitis in the Setting of Biologic Therapy for Psoriasis and Recurrent Cutaneous Methicillin-Resistant
Peter A Young1, Michael W Su1, Megan S Inkeles1
1Mr. Young and Drs. Su and Kuo are from the Department of Dermatology, Permanente Medical Group, Sacramento, California. Dr. Inkeles is from the Department of Dermatology, Permanente Medical Group, Santa Clara, California. Drs. Kiuru and Fung are from the Department of Dermatopathology, University of California School of Medicine, Davis.
Abstract:
IgA vasculitis is a form of cutaneous small-vessel leukocytoclastic vasculitis (LCV) that has various triggers, including anti-tumor necrosis factor (TNF) α therapy. As the use of more targeted biologic therapies such as the IL-17 inhibitor secukinumab increases, so do reports of associated adverse events. Herein, we describe an uncommon case of IgA vasculitis in a man undergoing biologic therapy with adalimumab and secukinumab for psoriasis with recurrent cutaneous methicillin-resistant Staphylococcus aureus (MRSA) colonization. A review of the current literature also is provided.
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