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Updated: Aug 19, 2025

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
Published on: October 3, 2019
Online Databases of Genome Editing in Cardiovascular and Metabolic Diseases
Paula Carrillo-Rodriguez1, Javier Martinez-Lopez1, Laura Gómez-Hernández2
1Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Granada, Spain.
Abstract:
Metabolic and cardiovascular diseases are world-concerning pathologies that affect an important percentage of the population. Nowadays, advances in the genetic background of these diseases allow new approaches to models and therapies, as well as different gene edition trials. Furthermore, technological improvements in gene editing go along with the development of new online and biocomputational tools that provide us alternative ways to explore pathologies. In this chapter, historical gene editing methods are discussed but focusing on CRISPR-Cas system in detail and also online resources available to perform these types of experiments. Here, the different strategies for gene editing and their online tools are gathered, putting the light on its application in the study and treatment of cardiovascular and metabolic diseases.
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