Impact of Radiation on Male Fertility

In today's time, environmental aspects, lifestyle changes, and person's health coalesce to form stupendous impact on the fertility. All of us are knowingly or unknowingly exposed to several types of radiation. These can lead to collection of early and delayed adverse effects of which infertility is one. A spurt in the number of cases of male infertility may be attributed to intense exposure to heat, pesticides, radiations, radioactivity, and other hazardous substances. Radiation both ionizing and non-ionizing can lead to adverse effects on spermatogenesis. Though thermal and non-thermal interactions of radiation with biological tissue can't be ruled out, most studies emphasize on the generation of reactive oxygen species (ROS). In addition, radiation pathophysiology also involves the role of kinases in cellular metabolism, endocrine system, genotoxicity, and genomic instability. In this study, we intend to describe a detailed literature on the impact of ionizing and non-ionizing radiation on male reproductive system and understand its consequences leading to the phenomenon of male infertility.