A Perspective on Reproductive Toxicity of Metallic Nanomaterials

Nanotechnological tools have been greatly exploited in all possible fields. However, advancement of nanotechnology has raised concern about their adverse effects on human and environment. These deleterious effects cannot be ignored and need to be explored due to safety purpose. Several recent studies have demonstrated possible health hazard of nanoparticles on organism. Moreover, studies showed that toxicity of metallic nanomaterial could also lead to reproductive toxicity. Various deleterious effects have demonstrated decreased sperm motility, increased abnormal spermatozoa, altered sperm count, and altered sperm morphology. Morphological and ultrastructural changes also have been reported due to the accumulation of these nanomaterials in reproductive organs. Nonetheless, studies also suggest crossing of metallic nanoparticles through blood testes barrier and generation of oxidative stress which plays major role in reproductive toxicity. In the present study, we have incorporated updated information by gathering all available literature about various metallic nanomaterials and risk related to reproductive system.