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[Research progress of persistent hyperplastic primary vitreous with Peters anomaly]
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China.
[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|December 8, 2022
Summary
Persistent hyperplastic primary vitreous and Peters anomaly are rare congenital eye conditions that can occur together. This review covers their development, genetics, and treatment to aid clinical practice and research.
Area of Science:
- Ophthalmology
- Developmental Biology
- Genetics
Background:
- Persistent hyperplastic primary vitreous (PHPV) results from failed regression of embryonic primary vitreous.
- Peters anomaly is a monogenetic disorder causing congenital anterior segment dysgenesis.
- These conditions can co-occur and be linked to systemic abnormalities.
Conclusions:
- Co-occurrence of PHPV and Peters anomaly requires comprehensive understanding.
- Further gene detection research is crucial for improved diagnosis and treatment.
- This review provides a foundation for clinical management and future research directions.
