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Mapping Pediatric Spinal Cord Development with Age.

Ashwin Kumar1, Simon Vandekar2, Kurt Schilling3

  • 1Computer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.

Proceedings of Spie--The International Society for Optical Engineering
|December 12, 2022
PubMed
Summary
This summary is machine-generated.

Pediatric spinal cord growth shows faster development in the upper cervical (C2-C3) and mid-thoracic (T3-T8) regions. This research provides crucial data for understanding pediatric spinal morphometry and clinical interventions.

Keywords:
Pediatricscord maturationmorphometryrandom effectsspinal cord developmentvolume change

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Area of Science:

  • Neuroimaging
  • Developmental Biology
  • Pediatric Radiology

Background:

  • Pediatric spinal cord morphometry is understudied due to imaging challenges and research focus on pathology.
  • Existing pediatric brain studies show age and gender-related differences in white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF).
  • Understanding pediatric spinal cord growth is vital for developing clinical growth models.

Purpose of the Study:

  • To characterize cervical and thoracic spinal cord growth and morphometry changes in a healthy pediatric population.
  • To establish a baseline for normal pediatric spinal cord development.
  • To inform clinical decision-making for spinal interventions and radiological analysis.

Main Methods:

  • Retrospective analysis of high-resolution multi-echo gradient echo (mFFE) MRI scans from 63 pediatric patients (0.83-17.67 years).
  • Customized semi-automatic processing pipeline using Spinal Cord Toolbox (SCT) for image registration and analysis.
  • Calculation of Jacobian determinants and scalar averaging of WM, GM, and specific spinal cord funiculi to assess volumetric changes.

Main Results:

  • The upper cervical spinal cord (C2-C3) and mid-thoracic spinal cord (T3-T8) exhibit faster growth rates compared to other regions.
  • Age-related differences in spinal cord morphometry were quantified using Jacobian scalars.
  • Data provides insights into differential growth patterns across pediatric spinal cord levels.

Conclusions:

  • The study identifies specific regions of accelerated growth within the pediatric cervical and thoracic spinal cord.
  • Findings contribute to a better understanding of normal spinal cord development in children.
  • This knowledge is essential for accurate radiological interpretation and guiding interventions in pediatric spinal conditions.