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Clinical Findings Predicting Posttraumatic Endophthalmitis after Repair of Open Globe Injuries

Marwan A Abouammoh1, Waleed K Alsarhani1, Abdulrahman Aljasser1

  • 1Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ocular Immunology and Inflammation
|December 12, 2022
PubMed

Insights

Risk factors for posttraumatic endophthalmitis include poor vision, rural injury settings, contaminated wounds, and lens injuries. Intravitreal antibiotics at primary repair reduced this risk.

Area of Science:

  • Ophthalmology
  • Trauma Surgery

Background:

  • Open globe injuries pose a significant risk for endophthalmitis.
  • Endophthalmitis following ocular trauma can lead to severe vision loss.

Purpose of the Study:

  • To identify risk factors associated with developing endophthalmitis after open globe injury repair.
  • To evaluate the effectiveness of prophylactic interventions in preventing posttraumatic endophthalmitis.

Main Methods:

  • Retrospective chart analysis of 1303 patients undergoing open globe injury repair.
  • Data collected from May 1996 to December 2019.
  • Univariate analysis to identify significant predictors of endophthalmitis.

Main Results:

  • Clinically suspected endophthalmitis occurred in 2.8% of eyes, with culture-proven cases in 1.1%.
  • Significant predictors for suspected endophthalmitis included poor initial visual acuity, rural injury setting, contaminated wounds, and lens injury.
  • Prophylactic intravitreal antibiotics at primary repair in high-risk eyes decreased endophthalmitis risk (OR: 2.28; 95% CI, 1.07-4.86; p = .033).

Conclusions:

  • Poor initial visual acuity, rural injury settings, contaminated wounds, and lens injuries are associated with increased risk of posttraumatic endophthalmitis.
  • Prophylactic intravitreal antibiotics administered during primary repair can mitigate the risk of endophthalmitis in high-risk eyes.
Abstract

Keywords:
Antimicrobial prophylaxisendophthalmitisintravitreal antibioticsopen globe injuries

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