Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite
Gopalkumar Rakesh1,2, Mark W Logue3,4, Emily Clarke-Rubright1,2
1Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.
Brain Connectivity
|December 13, 2022
Summary
Brain imaging reveals altered structural covariance networks in posttraumatic stress disorder (PTSD). Centrality differences in occipital regions and visual network modularity changes suggest early cortical remodeling in PTSD patients.
Area of Science:
- Neuroimaging
- Graph Theory
- Brain Anatomy
Background:
- Posttraumatic stress disorder (PTSD) is associated with brain pathology, measurable through cortical thickness (CT) and surface area (SA).
- Structural covariance networks (SCNs) model brain region relationships using correlations, offering insights into network organization.
Conclusions:
- Structural covariance in PTSD is linked to distinct centrality in occipital areas and altered VN modularity.
- Findings suggest a cortical remodeling process in PTSD that may begin early in life, potentially preceding trauma or disorder onset.
- Centrality and modularity are valuable graph theory metrics for understanding brain network alterations in PTSD and may inform therapeutic targets.
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