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Non-invasive Detection of Persistent Cortical Hypoxia in Multiple Sclerosis Using Frequency Domain Near-Infrared
Damilola D Adingupu1, T Evans2,3,4, A Soroush2,3,4
1Department of Radiology, University of Calgary, Calgary, Canada. deborah.adingupu@ucalgary.ca.
Advances in Experimental Medicine and Biology
|December 17, 2022
Summary
Hypoxia, or low oxygen, persists long-term in most multiple sclerosis (MS) patients. This chronic hypoxia may be linked to disease progression in individuals with MS.
Area of Science:
- Neurology
- Physiology
- Medical Imaging
Background:
- Hypoxia (low oxygen) and inflammation are implicated in numerous human diseases.
- Multiple Sclerosis (MS) is a neurological condition where hypoxia may influence inflammatory processes.
Purpose of the Study:
- To investigate the chronicity of cortical grey matter hypoxia in MS patients over a year.
- To determine if hypoxia in MS is a persistent condition.
Main Methods:
- Utilized frequency-domain near-infrared spectroscopy (fdNIRS) to measure cortical grey matter oxygenation.
- Assessed hypoxia in MS participants at baseline and again at a follow-up of 12 months or later.
Main Results:
- Chronic hypoxia was observed in 80% of MS participants at the one-year follow-up.
- A majority of individuals with MS remained hypoxic, with fewer returning to normal oxygen levels (normoxia).
Conclusions:
- Hypoxia in the cortical grey matter of MS patients is a persistent condition, lasting for at least a year.
- The persistence of hypoxia suggests a potential relationship with multiple sclerosis disease progression.
