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Updated: Aug 16, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Cobalt-Catalyzed Thioamide Directed C(arene)-H Annulation with Ynamide: Regioselective Access to 2-Amidoindenones
Somratan Sau1, Arghadip Ghosh1, Majji Shankar1
1School of Chemistry, University of Hyderabad, Hyderabad 500046, India.
Abstract:
Demonstrated herein is an unprecedented thioamide-directed cobalt (Co)-catalyzed umpolung annulation of sulfoximines enabled aryl thioamide with ynamide for the synthesis of highly substituted 2-amidoindenones. The cyclization is regioselective, making β-C-C and α-C-CO bonds. The transformation is even successful on a gram scale, exhibiting broad scope with labile functional group tolerance and constructing 43 unusual 2-amidoindenones of structural diversity. Control experiments and mechanistic investigation validate the regioselectivity outcome in this transformation.
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