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Chromosome Translocation t(10;19)(q26;q13) in a CIC-sarcoma

Ioannis Panagopoulos1, Kristin Andersen2, Ludmila Gorunova2

  • 1Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway; ioannis.panagopoulos@rr-research.no.

In Vivo (Athens, Greece)
|January 2, 2023
PubMed
Summary

This study identifies a novel chromosomal translocation, t(10;19)(q26;q13), in CIC-sarcomas, leading to CIC::DUX4 fusion transcripts. These fusions result in truncated CIC proteins, potentially driving tumor development.

Keywords:
CIC rearrangementCIC-sarcomaCIC::DUX4 fusionchromosome translocationproline rich regiont(10;19)(q26;q13)truncated CIC protein

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