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Macronutrients Not Micronutrients Are Associated With the Risk of Pancreatic Cancer: A Jordanian Case-Control Study
Reema F Tayyem, Mohammed O Ibrahim1, Haya Abuhijleh2
1Department of Nutrition and Food Technology, Faculty of Agriculture, Mu'tah University, Karak.
Pancreas
|January 6, 2023
Summary
High intake of proteins, carbohydrates, sugars, and fats is linked to increased pancreatic cancer risk. Conversely, polyunsaturated fats and omega-3 fatty acids showed no association with pancreatic cancer risk in this Jordanian study.
Area of Science:
- Nutritional Epidemiology
- Oncology
- Public Health
Background:
- Diet is a modifiable risk factor for pancreatic cancer.
- Understanding nutrient-specific associations is crucial for prevention strategies.
Purpose of the Study:
- To investigate the association between macromicronutrient intake and pancreatic cancer risk.
- Focus on a Jordanian population to understand regional dietary impacts.
Main Methods:
- Case-control study with 100 pancreatic cancer patients and 309 controls.
- Dietary intake assessed via a validated food-frequency questionnaire.
- Multinomial logistic regression used for statistical analysis.
Main Results:
- Higher intake of carbohydrates, sugars, fats, saturated fats, monounsaturated fats, trans fats, cholesterol, and vitamin B3 associated with increased pancreatic cancer risk.
- No significant association found for polyunsaturated fats, omega-3, and other vitamins/minerals.
Conclusions:
- Dietary patterns rich in proteins, carbohydrates, sugars, and fats may promote pancreatic carcinogenesis.
- Specific nutrient intake plays a role in pancreatic cancer development.
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