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Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications
Ryan C Locke1,2, Hannah M Zlotnick1,2,3, Brendan D Stoeckl1,2,3
1Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Advanced Healthcare Materials
|January 19, 2023
Summary
This study analyzes 20 years of orthopedic tissue engineering (OTE) publications to identify key trends. It reveals accelerated growth in anatomic orthopedic tissue engineering (AOTE) for specific tissues, guiding future musculoskeletal therapies.
Area of Science:
- Orthopedic Tissue Engineering
- Biomaterials Science
- Regenerative Medicine
Background:
- The field of tissue engineering (TE) and orthopedic TE (OTE) has seen extensive growth over the last two decades.
- Understanding emergent trends in OTE is crucial for developing impactful musculoskeletal therapies.
Purpose of the Study:
- To systematically analyze publication trends in OTE over 20 years.
- To identify key terms and categories driving innovation in orthopedic repair technologies.
- To formulate design criteria for future anatomic constructs.
Main Methods:
- A hierarchical systematic search method was employed.
- Trend analysis using connected network mapping of key terms was performed.
- Publication data was analyzed within discrete time intervals.
Main Results:
- An accelerated publication rate was identified for anatomic orthopedic tissue engineering (AOTE) concerning osteochondral defects, tendons, menisci, and entheses.
- Key emergent categories driving innovation include biomaterials, delivery methods, and 3D printing/biofabrication.
- A significant convergence of material types and descriptors across different tissue types was observed.
Conclusions:
- The study identifies large-scale trends and predicts new directions in orthopedic repair.
- Emergent categories in AOTE are shaping future materials and technologies for musculoskeletal therapies.
- Design criteria are proposed for future anatomic constructs mimicking native tissue form and function.
