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Choroidal Vascular Density Quantification in High Myopia with or without Choroidal Neovascularization Using Optical
Xuehui Lu1, Guihua Zhang1, Lingping Cen1
1Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou 515041, Guangdong, China.
Journal of Ophthalmology
|January 30, 2023
Summary
High myopia patients with choroidal neovascularization are older and have reduced choroidal vascular density. Optical coherence tomography angiography (OCTA) can help identify these patients for intervention.
Area of Science:
- Ophthalmology
- Medical Imaging
- Vascular Biology
Background:
- High myopia is a significant risk factor for various ocular pathologies.
- Choroidal neovascularization (CNV) is a sight-threatening complication associated with high myopia.
- Understanding the vascular changes in the choroid is crucial for managing high myopia complications.
Purpose of the Study:
- To analyze choroidal vascular density alterations in high myopia.
- To compare these alterations in eyes with and without choroidal neovascularization (CNV).
- To investigate the role of optical coherence tomography angiography (OCTA) in assessing these changes.
Main Methods:
- A cross-sectional, observational study involving 60 high-myopia eyes.
- Comprehensive ophthalmic assessments including visual acuity, intraocular pressure, fundus photography, and OCTA.
- Univariate and multivariate analyses to compare choroidal vascular density, age, and thickness between groups with and without CNV.
Main Results:
- Eyes with CNV were significantly older (48.43 years) than those without (28.83 years).
- Choroidal thickness was significantly lower in the CNV group (68.81 μm) compared to the normal group (137.80 μm).
- Choroidal vascular density was significantly reduced in the CNV group (67.54) versus the normal group (82.43).
- Reduced choroidal vascular density and older age were independent factors associated with CNV in high myopia.
Conclusions:
- Decreased choroidal vascular density and older age are key factors in the development of CNV in high myopia.
- OCTA is a valuable tool for identifying high myopic patients at risk for CNV.
- Early identification may facilitate timely intervention to prevent vision loss.
