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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Overview
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Aug 12, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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[Allergology: what's new in 2022].

Sabela Pérez-Codesido1, Daniele Allali1, Joerg Seebach1

  • 1Division d'immunologie et d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux universitaires de Genève et Faculté de médecine, Université de Genève, 1211 Genève 4.

Revue Medicale Suisse
|February 1, 2023
PubMed
Summary

The basophil activation test (BAT) shows potential for diagnosing COVID-19 vaccine reactions. Lirentelimab and tezepelumab offer new treatments for allergic conditions, while dietary guidelines aim to prevent infant allergies.

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Area of Science:

  • Immunology and Allergy Research
  • Vaccine Safety and Efficacy
  • Pediatric Allergy Prevention

Context:

  • Extensive research has focused on SARS-CoV-2 vaccine reactions, with the basophil activation test (BAT) emerging as a key diagnostic tool.
  • Lirentelimab, a monoclonal antibody, demonstrates efficacy in managing allergic rhinoconjunctivitis symptoms and comorbidities.
  • Tezepelumab, another monoclonal antibody, has shown significant reduction in exacerbations for severe asthma patients.

Purpose:

  • To explore the utility of the basophil activation test (BAT) in identifying adverse reactions to COVID-19 vaccines.
  • To review the therapeutic potential of lirentelimab in allergic rhinoconjunctivitis and tezepelumab in severe asthma.
  • To highlight updated European Academy of Allergy and Clinical Immunology (EAACI) guidelines on infant feeding practices for allergy prevention.

Summary:

  • The basophil activation test (BAT) is investigated as a diagnostic method for SARS-CoV-2 vaccine hypersensitivity.
  • Clinical studies show lirentelimab effectively reduces symptoms in allergic rhinoconjunctivitis and tezepelumab decreases exacerbations in severe asthma.
  • New EAACI guidelines advise against early cow's milk supplementation in neonates to mitigate the risk of cow's milk allergy.

Impact:

  • Potential for improved diagnostics in vaccine adverse reactions.
  • Advancements in targeted biologic therapies for allergic diseases and severe asthma.
  • Evidence-based dietary recommendations for reducing infant allergy prevalence.