Related Experiment Video
Updated: Aug 12, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
[Allergology: what's new in 2022]
Sabela Pérez-Codesido1, Daniele Allali1, Joerg Seebach1
1Division d'immunologie et d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux universitaires de Genève et Faculté de médecine, Université de Genève, 1211 Genève 4.
Abstract:
The study of reactions to SARS-CoV-2 vaccines has marked a large part of the literature in the last two years, using the basophil activation test (BAT) as a potential diagnostic tool for reactions to Covid-19 vaccines. In allergic rhinoconjunctivitis, lirentelimab (a humanised monoclonal antibody against lectin 8), reduces patients' symptoms and atopic comorbidities. In severe asthma, tezepelumab (human monoclonal antibody) reduces the annual asthma exacerbation rate over 52 weeks. In terms of diet, the new EAACI guidelines recommend avoiding cow's milk supplementation in infants during the first three days of life to reduce the risk of cow's milk allergy.
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