Photoinduced Decarboxylative C3-H Alkylation of Quinoxalin-2(1H)-ones
Akash Bisoyi1, Alisha Rani Tripathy1, Girish Suresh Yedase1
1School of Chemistry, Indian Institute of Science Education and Research, Thiruvananthapuram 695551, India.
Abstract:
An efficient, catalyst- and additive-free, visible-light-driven radical C3-H alkylation of quinoxalin-2(1H)-one derivatives has been developed. This reaction utilizes alkyl-NHP-esters as an alkyl radical donor and quinoxalin-2(1H)-one derivatives as an alkyl radical acceptor. The operationally simple protocol works under mild reaction conditions and tolerates a variety of functional groups. Furthermore, the synthetic utility of the methodology was successfully implemented for synthesizing biologically relevant C3-alkyl substituted quinoxalin-2(1H)-one derivatives.
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