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Multi-stimuli-responsive molecular fluorescent probes for bioapplications.

Shan-Shan Xue1, Yuanyuan Li1, Wei Pan1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China. lina@sdnu.edu.cn.

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Summary

This review summarizes advances in multi-stimuli-responsive fluorescent probes for detecting disease biomarkers. These probes, based on organic molecules and metal complexes, offer sensitive and high-contrast detection for bio-applications.

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Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Materials Science

Background:

  • Stimuli-responsive fluorescent probes are crucial for monitoring biological systems.
  • Existing probes offer advantages like high sensitivity, resolution, and contrast.
  • Development of multi-responsive probes enhances detection capabilities for complex biological environments.

Purpose of the Study:

  • To review the progress of multi-stimuli-responsive fluorescent probes.
  • To highlight applications of organic molecule- and metal complex-based probes in detecting disease biomarkers.
  • To discuss current challenges and future directions for these probes in biological systems.

Main Methods:

  • Literature review of recent advancements in stimuli-responsive fluorescent probe development.
  • Focus on probes responding to multiple stimuli for enhanced specificity and sensitivity.
  • Analysis of probe designs utilizing organic molecules and metal complexes for bio-applications.

Main Results:

  • Summary of diverse multi-stimuli-responsive probes, including organic and metal-based designs.
  • Demonstration of their utility in detecting various biomarkers associated with cancer and other diseases.
  • Identification of key design principles enabling multi-stimuli responsiveness for biological detection.

Conclusions:

  • Multi-stimuli-responsive fluorescent probes show significant promise for sensitive and specific biomarker detection in biological systems.
  • Organic molecules and metal complexes are versatile platforms for developing advanced fluorescent probes.
  • Addressing current challenges will pave the way for broader clinical applications and future innovations in molecular imaging and diagnostics.