Towards multiomic analysis of oral mucosal pathologies

Area of Science:

• Immunology
• Oral Pathology
• Translational Medicine

Background:

• Oral mucosal pathologies significantly impact quality of life globally.
• Current treatments for oral diseases are often not curative and lack study.
• The host immune system is central to the development and resolution of oral mucosal diseases.

Purpose of the Study:

• To review the immune system's role in oral mucosal pathologies.
• To highlight how understanding immunology can improve diagnostics and therapeutics.
• To emphasize the need for mechanistic biomarkers and targeted immunotherapies.

Main Methods:

• Review of existing literature on immunology and oral mucosal pathologies.
• Emphasis on multiomic and single-cell approaches.
• Analysis of immunological mechanisms in disease pathogenesis.

Main Results:

• The immune system critically influences oral mucosal pathology development, maintenance, and resolution.
• Multiomic and single-cell techniques offer integrative views of these diseases.
• These approaches can yield unifying and clinically relevant biological signatures.

Conclusions:

• A deeper understanding of oral immunology is crucial for advancing diagnostics and treatments.
• Targeted immunotherapies and personalized approaches hold promise for better patient outcomes.
• Integrative multiomic and single-cell data can provide critical insights into oral mucosal pathologies.