Related Experiment Video
Updated: Aug 9, 2025

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
Published on: May 30, 2017
Cholera Dynamics and the Emergence of Pandemic Vibrio cholerae
Deepak Balasubramanian1,2, Mario López-Pérez1,2,3, Salvador Almagro-Moreno4,5
1Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Abstract:
Cholera is a severe diarrheal disease caused by the aquatic bacterium Vibrio cholerae. Interestingly, to date, only one major clade has emerged to cause pandemic disease in humans: the clade that encompasses the strains from the O1 and O139 serogroups. In this chapter, we provide a comprehensive perspective on the virulence factors and mobile genetic elements (MGEs) associated with the emergence of pandemic V. cholerae strains and highlight novel findings such as specific genomic background or interactions between MGEs that explain their confined distribution. Finally, we discuss pandemic cholera dynamics contextualizing them within the evolution of the bacterium.
Related Concept Videos
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Steps in Outbreak Investigation
Principles of Disease Surveillance
Causality in Epidemiology
Viral Replication: Lysogenic Cycle
Development of Antibiotic Resistance

