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The function of γδ T cells in humoral immune responses
Lingfeng Qiu1, Yixi Zhang1, Xun Zeng2
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Purpose:
The purpose of this review is to discuss the role of γδ T cells played in humoral immune responses.
Background:
The γδ T cell receptor (γδ TCR) recognizes antigens, including haptens and proteins, in an MHC-independent manner. The recognition of these antigens by γδ TCRs crosses antigen recognition by the B cell receptors (BCRs), suggesting that γδ T cells may be involved in the process of antigen recognition and activation of B cells. However, the role of γδ T cells in humoral immune responses is still less clear.
Methods:
The kinds of literature about the γδ T cell-B cell interaction were searched on PubMed with search terms, such as γδ T cells, antibody, B cell responses, antigen recognition, and infection.
Results:
Accumulating evidence indicates that γδ T cells, independent of αβ T cells, participate in multiple steps of humoral immunity, including B cell maturation, activation and differentiation, antibody production and class switching. Mechanically, γδ T cells affect B cell function by directly interacting with B cells, secreting cytokines, or modulating αβ T cells.
Conclusion:
In this review, we summarize current knowledge on how γδ T cells take part in the humoral immune response, which may assist future vaccine design.
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