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Update in Human Immunodeficiency Virus and Aging.
Jason R Faulhaber1, Anthony W Baffoe-Bonnie1, Krisann K Oursler2
1Virginia Tech Carilion School of Medicine, Carilion Clinic, Division of Infectious Diseases, 213 McClanahan St SW, Roanoke, VA 24014, USA.
Infectious Disease Clinics of North America
|February 22, 2023
Summary
People with human immunodeficiency virus (HIV) experience accelerated aging due to unique factors, increasing their risk for age-related diseases. Enhanced vigilance and interventions are crucial for their care.
Area of Science:
- Gerontology
- Infectious Diseases
- Immunology
Background:
- Effective antiretroviral therapy (ART) has significantly increased the lifespan of people with human immunodeficiency virus (PWH).
- PWH now face health challenges and clinical conditions commonly associated with aging.
- The aging process in PWH is distinct from that in HIV-negative individuals.
Purpose of the Study:
- To investigate the factors contributing to accelerated aging in PWH.
- To highlight the increased risk of age-related comorbidities in PWH.
- To emphasize the need for tailored clinical vigilance and interventions for aging PWH.
Main Methods:
- This study synthesizes current research on aging in PWH.
- It examines the interplay of molecular, microbiologic, and pharmacologic factors.
- The focus is on identifying mechanisms driving accelerated aging and comorbidity risk.
Main Results:
- Accelerated aging in PWH is driven by a complex interaction of factors.
- PWH exhibit a higher susceptibility to age-related comorbidities.
- These comorbidities necessitate increased monitoring and specific interventions.
Conclusions:
- The aging process for PWH is significantly altered by HIV and its treatment.
- Understanding these unique aging pathways is critical for improving long-term health outcomes.
- Routine care for PWH must incorporate strategies to manage accelerated aging and associated health risks.
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