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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

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Anticoagulation Regimens in Pregnancy.

Antonio Saad¹, Melody Safarzadeh¹, Megan Shepherd¹

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555, USA.

Obstetrics and Gynecology Clinics of North America

|February 23, 2023

Summary

This summary is machine-generated.

This article provides guidance on anticoagulation therapy during pregnancy, covering antepartum, intrapartum, and postpartum care. It details screening, dosing, surveillance, and management of heparin therapies for expectant mothers.

Keywords:

Anticoagulation Low-molecular-weight heparin Postpartum Pregnancy Thrombophilia Unfractionated heparin Venous thromboembolism

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Area of Science:

Obstetrics and Gynecology
Hematology
Pharmacology

Background:

Anticoagulation therapy is critical for managing thromboembolic disorders in pregnancy.
Current guidelines for anticoagulation in pregnancy require careful consideration of maternal and fetal safety.
Managing anticoagulation presents unique challenges throughout pregnancy and the postpartum period.

Purpose of the Study:

To outline current recommendations for anticoagulation therapy in pregnant patients.
To review screening strategies, dosing, surveillance, and reversal agents for anticoagulation.
To discuss challenges in heparin management and postpartum thromboprophylaxis.

Main Methods:

Review of current clinical practice guidelines and relevant literature.
Analysis of screening tools for anticoagulation candidacy.
Synthesis of information on heparin transition, reversal, and regional anesthesia implications.

Main Results:

Comprehensive overview of antepartum, intrapartum, and postpartum anticoagulation recommendations.
Detailed strategies for patient screening and medication management.
Discussion on managing transitions between different heparin types and postpartum prophylaxis.

Conclusions:

Effective anticoagulation management in pregnancy requires tailored approaches based on individual risk assessment.
Optimal surveillance and timely intervention are crucial for patient safety.
Understanding the nuances of heparin therapy and postpartum thromboprophylaxis improves outcomes.