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Long-Term Adherence to Adjuvant Endocrine Therapy Following Various Radiotherapy Modalities in Early Stage Hormone
Kristin A Ward1, Donald A Muller1, Sunil W Dutta2
1Department of Radiation Oncology, University of Virginia, Charlottesville, VA.
Clinical Breast Cancer
|March 3, 2023
Summary
Adherence to long-term endocrine therapy was lower for early-stage breast cancer patients receiving intraoperative radiation therapy (IORT) compared to other radiation methods. This suggests further research into radiation therapy efficacy without endocrine therapy is needed.
Area of Science:
- Oncology
- Radiation Oncology
- Endocrinology
Background:
- Adjuvant endocrine therapy (AET) is crucial for hormone receptor-positive early-stage breast cancer.
- Radiation therapy (RT) modalities vary, potentially impacting treatment adherence.
- Understanding adherence across different RT techniques is vital for optimizing patient outcomes.
Purpose of the Study:
- To compare long-term adjuvant endocrine therapy (AET) adherence rates among early-stage breast cancer patients treated with different radiation therapy (RT) modalities.
- To identify RT modalities associated with significant differences in AET adherence.
Main Methods:
- Retrospective review of 114 patients with stage 0, I, or IIA hormone receptor-positive breast cancer treated with RT from 2013-2015.
- Comparison of AET adherence following whole breast radiotherapy (WBI), partial breast irradiation (PBI), and intraoperative radiation therapy (IORT).
Main Results:
- Overall AET adherence was approximately 64% at 2 years and 56% at 5 years.
- Patients receiving IORT showed lower AET adherence (51% at 2 years, 40% at 5 years) compared to other RT modalities.
- Ductal carcinoma in situ (DCIS) histology and IORT were independently associated with decreased AET adherence (P < 0.05).
Conclusions:
- Ductal carcinoma in situ (DCIS) histology and intraoperative radiation therapy (IORT) are linked to reduced long-term adherence to adjuvant endocrine therapy (AET).
- Further investigation into the effectiveness of radiation therapy interventions like partial breast irradiation (PBI) and IORT in patients not receiving AET is warranted.
