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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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Antiepileptic Drugs: Glutamate Antagonists01:14

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Focal Seizures
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Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Related Experiment Video

Updated: Aug 8, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Chorea Associated with Lamotrigine Use.

Sofia Rael1, Negin Badihian2, Kelsey M Smith2

  • 1Mayo Clinic Alix School of Medicine, Rochester, MN.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|March 6, 2023
PubMed
Summary
This summary is machine-generated.

Lamotrigine use can rarely cause chorea, a movement disorder. This association is more likely when patients take other centrally acting medications alongside lamotrigine.

Keywords:
Choreaantiseizure medicationsdepressionhyperkineticlamotriginemovement disorder

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Movement disorders, specifically chorea, are a debated side effect of lamotrigine.
  • Clinical features of lamotrigine-associated chorea are not well-defined.

Approach:

  • A retrospective chart review identified patients with chorea using lamotrigine between 2000-2022.
  • A literature review supplemented the analysis with additional reported cases.

Key Points:

  • One case showed a clear temporal and dose-related link between lamotrigine and chorea in a patient with bipolar disorder.
  • Concurrent use of other centrally acting medications may be a contributing factor.
  • Chorea resolved in some cases after discontinuing lamotrigine.

Conclusions:

  • Chorea is an infrequent adverse effect of lamotrigine.
  • The co-administration of lamotrigine with other central nervous system medications may increase the risk of developing chorea.