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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
Selective photodynamic eradication of senescent cells with a β-galactosidase-activated photosensitiser
Junlong Xiong1, Ying-Kit Cheung2, Wing-Ping Fong2
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. dkpn@cuhk.edu.hk.
Abstract:
A β-galactosidase-responsive photosensitiser has been designed and synthesised. It contains a galactosyl substrate, a boron dipyrromethene-based photosensitising unit and a black hole quencher 2 connected via an AB2-type self-immolative linker. This novel photosensitiser can be selectively activated by the senescence-associated β-galactosidase in senescent cells, leading to restoration in fluorescence emission and effective killing of the cells via photodynamic action.
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