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Steatorrhea associated with meclofenamate sodium therapy

D D Moeller1

  • 1Department of Internal Medicine, University of Kansas Medical Center, Kansas City.

The American Journal of Gastroenterology
|December 1, 1987
PubMed

Insights

Fenamates, a type of nonsteroidal anti-inflammatory drug, can cause diarrhea and malabsorption. This study presents a case of steatorrhea linked to meclofenamate sodium, highlighting potential gastrointestinal side effects.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Fenamates are nonsteroidal anti-inflammatory drugs (NSAIDs) known for gastrointestinal side effects.
  • Diarrhea is a common side effect, but malabsorption is rarely reported with fenamates.

Observation:

  • This report details a case of steatorrhea (fat malabsorption) in a patient treated with meclofenamate sodium.
  • Previous reports of malabsorption with fenamates are limited, with only three cases involving mefenamic acid.

Findings:

  • Fenamates interfere with net fluid absorption in the small intestine.
  • Histological abnormalities of the small intestine are observed in patients undergoing fenamate therapy.

Implications:

  • The precise mechanism causing malabsorption during fenamate therapy remains unclear.
  • This case adds to the understanding of potential severe gastrointestinal adverse effects of fenamate NSAIDs.

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