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Steatorrhea associated with meclofenamate sodium therapy
1Department of Internal Medicine, University of Kansas Medical Center, Kansas City.
The American Journal of Gastroenterology
|December 1, 1987
Summary
Fenamates, a type of nonsteroidal anti-inflammatory drug, can cause diarrhea and malabsorption. This study presents a case of steatorrhea linked to meclofenamate sodium, highlighting potential gastrointestinal side effects.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Fenamates are nonsteroidal anti-inflammatory drugs (NSAIDs) known for gastrointestinal side effects.
- Diarrhea is a common side effect, but malabsorption is rarely reported with fenamates.
Observation:
- This report details a case of steatorrhea (fat malabsorption) in a patient treated with meclofenamate sodium.
- Previous reports of malabsorption with fenamates are limited, with only three cases involving mefenamic acid.
Findings:
- Fenamates interfere with net fluid absorption in the small intestine.
- Histological abnormalities of the small intestine are observed in patients undergoing fenamate therapy.
Implications:
- The precise mechanism causing malabsorption during fenamate therapy remains unclear.
- This case adds to the understanding of potential severe gastrointestinal adverse effects of fenamate NSAIDs.
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