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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
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Adverse Outcomes Associated With Interleukin-6 in Patients Recently Hospitalized for Heart Failure With Preserved
Leanne Mooney1, Colette E Jackson1, Carly Adamson1
1School of Cardiovascular and Metabolic Health (L.M., C.E.J., C.A., P.W., R.C.M., J.J.V.M., P.S.J., M.C.P., N.N.L.), University of Glasgow, United Kingdom.
Circulation. Heart Failure
|March 10, 2023
Summary
Elevated interleukin-6 (IL-6) levels predict adverse outcomes in patients hospitalized with heart failure with preserved ejection fraction. Higher IL-6 is linked to increased risk of death and rehospitalization for heart failure.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- Inflammation is implicated in the pathophysiology of heart failure with preserved ejection fraction (HFpEF).
- Circulating inflammatory markers may identify high-risk patients post-hospitalization for HFpEF.
Purpose of the Study:
- To investigate if interleukin-6 (IL-6) levels predict adverse outcomes in patients hospitalized with HFpEF.
- To assess the association between IL-6 and mortality or heart failure rehospitalization.
Main Methods:
- Assessed IL-6 tertiles in 286 patients recently hospitalized with HFpEF.
- Used Cox-regression analysis, adjusting for risk factors like B-type natriuretic peptide (BNP).
- Evaluated associations with all-cause death, cardiovascular death, and subsequent heart failure hospitalization (sHFH).
Main Results:
- Higher IL-6 tertiles correlated with increased male sex, higher creatinine, and elevated high-sensitivity C-reactive protein (hsCRP).
- Patients in the highest IL-6 tertile had significantly higher rates of all-cause death, cardiovascular death, and sHFH.
- Each log unit increase in IL-6 independently predicted higher risks of all-cause death, cardiovascular death, and sHFH.
Conclusions:
- Interleukin-6 (IL-6) is an independent predictor of adverse outcomes in HFpEF patients post-hospitalization.
- Findings support the role of IL-6 in HFpEF pathophysiology and prognosis.
- Results are relevant for developing targeted anti-IL-6 therapies.
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