Related Experiment Video

Updated: Aug 7, 2025

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
09:50

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

Published on: August 27, 2015

8.3K

Zyxin is all you need: machine learning adherent cell mechanics

Matthew S Schmitt, Jonathan Colen, Stefano Sala

    Arxiv
    |March 13, 2023
    PubMed
    Summary

    Scientists developed a data-driven method to predict cell forces from images of single proteins. This approach reveals how cellular mechanics are encoded, advancing biophysical modeling in cell biology.

    More Related Videos

    Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads07:55

    Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

    Published on: March 8, 2017

    8.5K
    All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System09:55

    All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

    Published on: December 20, 2021

    3.0K

    Related Concept Videos

    Cell-matrix's Response to Mechanical Forces01:13

    Cell-matrix's Response to Mechanical Forces

    In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
    Anchoring junctions mechanically attach a cell to the...
    2.7K
    Cell Motility through Blebbing01:16

    Cell Motility through Blebbing

    Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
    Blebbing Through the Matrix
    In multicellular...
    2.0K
    Role of Myosin in Cell Migration01:18

    Role of Myosin in Cell Migration

    Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
    Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
    2.4K
    Tension Response at Adherens Junctions01:26

    Tension Response at Adherens Junctions

    The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
    α-Catenin as a Mechanosensory Protein
    The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
    2.7K
    Cytoskeletal Coordination in Cell Migration01:32

    Cytoskeletal Coordination in Cell Migration

    A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
    4.8K
    The Role of Actin and Myosin in Non-muscle Cells01:10

    The Role of Actin and Myosin in Non-muscle Cells

    Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
    3.6K