Targeting regulatory T cells for cardiovascular diseases

Area of Science:

• Immunology
• Cardiology
• Inflammation Research

Background:

• Cardiovascular diseases (CVDs) are a major global health burden, characterized by inflammatory processes.
• Regulatory T cells (Tregs), a subset of CD4+ T cells, are key regulators of immune responses and inflammation.
• The role of Tregs in CVDs is complex, involving both protective and potentially detrimental functions.

Purpose of the Study:

• To review the multifaceted role of Tregs in the pathogenesis and progression of cardiovascular diseases.
• To elucidate the mechanisms by which Tregs influence CVDs, including immune balance and inflammation.
• To highlight the emerging research on Treg plasticity and its implications for CVD treatment.

Main Methods:

• Literature review of preclinical and clinical studies on Tregs in cardiovascular diseases.
• Analysis of research focusing on Treg function, plasticity, and therapeutic targeting in CVD models.
• Synthesis of current understanding regarding Treg-mediated cardioprotection and potential adverse effects.

Main Results:

• Tregs play a significant role in modulating inflammation and immune responses in CVDs.
• Treg plasticity can lead to a loss of immunosuppressive function, potentially exacerbating CVDs.
• Targeting Tregs offers potential therapeutic strategies for CVDs, including immune modulation and regeneration.

Conclusions:

• Tregs are critical players in cardiovascular diseases, influencing inflammation and immune responses.
• Understanding Treg plasticity is essential for developing effective therapeutic strategies.
• Targeting Tregs holds promise for novel treatments aimed at preventing and managing CVDs.