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Updated: Aug 6, 2025

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Radiosynthesis of 18F-Labeled Arenesulfonyl Fluorides through Two-Bond Construction with [18F]Fluoride
Xiaoyun Deng1, Ziqiang Wang1, Huimin Zhou1
1Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, 430030 Wuhan, China.
Abstract:
A novel 18F labeling strategy was developed to directly construct aryl-SO2-18F from arenediazonium tosylates with a SO2 source and [18F]fluoride. This approach is compatible with a wide range of substrates and enabled the production of 18F-labeled drug-like derivatives through late-stage 18F fluorination, representing a significant advance in the radiosynthesis of 18F-labeled arenesulfonyl fluorides. A reactive 18F labeling synthon, bearing a maleimide-based prosthetic group, allowed for the generation of 18F-labeled temperature-sensitive biomolecules containing cysteine residues via maleimide-cysteine chemistry.
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