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Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders.

Santiago Ballaz1,2, Michel Bourin3

  • 1School of Biological Science and Engineering, Yachay Tech University, Urcuquí, Ecuador.

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|March 23, 2023
PubMed
Summary
This summary is machine-generated.

Anti-inflammatory drugs show therapeutic potential for psychiatric diseases by targeting neuroinflammation. Identifying immune biomarkers may personalize treatment for better outcomes in mental health.

Keywords:
Anti-inflammatory agentsCytokinesGlucocorticoidsInflammationMental disordersPsychoneuroimmunology

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Area of Science:

  • Neuroimmunology
  • Psychiatry

Background:

  • The brain and immune system have a bidirectional relationship.
  • Dysregulated inflammation contributes to psychiatric and neurological disorders.
  • Inflammation can be harmful to the central nervous system under certain conditions.

Approach:

  • Analyzes therapeutic potential of anti-inflammatory drugs for psychiatric diseases.
  • Reviews inflammatory response mechanisms in mental illnesses, focusing on cytokines and the HPA axis.
  • Examines clinical utility of various anti-inflammatory agents as adjuncts to psychiatric medications.

Key Points:

  • Immunotherapy, glucocorticoids, NSAIDs, and other agents show promise.
  • Selective cyclooxygenase-2 (COX-2) inhibitors like celecoxib are highlighted.
  • Understanding immune underpinnings is crucial for personalized treatment.

Conclusions:

  • Anti-inflammatory therapies hold significant promise in psychiatry.
  • Further research is needed to identify immune-related biomarkers for patient stratification.
  • Biomarkers can predict mental disease risk, prognosis, and response to anti-inflammatory therapy.