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Nocardia pseudobrasiliensis Co-infection in SARS-CoV-2 Patients
Emerging Infectious Diseases
|March 23, 2023
Summary
Nocardia spp. co-infection is rare but possible after COVID-19, especially in immunocompromised individuals. Early diagnosis and species-specific treatment are crucial for managing Nocardia pneumonia in these patients.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pulmonology
Background:
- Nocardia spp. are opportunistic pathogens, primarily affecting immunocompromised individuals.
- Co-infections with Nocardia spp. during or after SARS-CoV-2 infection are infrequently reported.
- Nocardia spp. can cause disseminated disease, posing a significant clinical challenge.
Observation:
- A case of Nocardia pseudobrasiliensis pneumonia is presented in a 52-year-old immunocompromised male following SARS-CoV-2 infection.
- A literature review on Nocardia spp. and SARS-CoV-2 co-infections was conducted.
- The patient's presentation highlights a potential, albeit rare, complication post-COVID-19.
Findings:
- Nocardia spp. infection should be considered in the differential diagnosis of pneumonia in immunocompromised hosts, irrespective of concurrent infections like COVID-19.
- Empiric treatment for nocardiosis often involves sulfonamides and carbapenems.
- Accurate species identification and susceptibility testing are essential for tailoring optimal antimicrobial therapy.
Implications:
- This case underscores the importance of maintaining a high index of suspicion for Nocardia spp. in immunocompromised patients presenting with pneumonia after SARS-CoV-2 infection.
- Timely diagnosis and appropriate treatment can improve outcomes for patients with Nocardia co-infections.
- Further research may elucidate the mechanisms underlying this co-infection and inform clinical management strategies.
Keywords:
Barajas-Ochoa ACOVID-19Nocardia pseudobrasiliensisRaybould JE. Nocardia pseudobrasiliensis co-infection in SARS-CoV-2 patients. Emerg Infect Dis. 2023 Apr [date cited]. https://doi.org/10.3201/eid2904.221439SARS-CoV-2Suggested citation for this article: Stamos DBUnited Statesbacteriaco-infectioncoronavirus diseasenocardiosisopportunistic infectionsrespiratory infectionssevere acute respiratory syndrome coronavirus 2More Related Videos
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