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Morpholine-modified permethyl β-cyclodextrin supramolecular nanoparticles for precise dual-targeted imaging.
Jie Niu1, Yao-Hua Liu1, Wenshi Xu1
1College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. ymzhang@nankai.edu.cn.
Chemical Communications (Cambridge, England)
|March 30, 2023
Summary
Researchers developed a novel ternary supramolecular assembly for dual-targeted cancer therapy and imaging. This advanced material enhances photodynamic effects and precisely targets both lysosomes and cancer cells.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Research
Background:
- Developing targeted cancer therapies is crucial for improving treatment efficacy and reducing side effects.
- Lysosomes and cancer cells represent key targets for novel therapeutic strategies.
- Supramolecular assemblies offer a versatile platform for combining therapeutic and diagnostic functionalities.
Purpose of the Study:
- To construct a ternary supramolecular assembly with dual-targeting capabilities for cancer cells and lysosomes.
- To evaluate the enhanced photodynamic effect of the supramolecular assembly compared to free porphyrin.
- To assess the potential of the assembly for precise dual-targeted imaging in cancer cells.
Main Methods:
- Fabrication of a ternary supramolecular assembly using morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified chitosan.
- Utilizing multivalent interactions for the assembly's construction.
- Comparative analysis of photodynamic effects and imaging capabilities with free porphyrin.
Main Results:
- The constructed ternary supramolecular assembly demonstrated a promoted photodynamic effect.
- The assembly achieved precise dual-targeted imaging, effectively visualizing both lysosomes and cancer cells.
- Folic acid modification facilitated targeted delivery to cancer cells, while the porphyrin component enabled lysosomal interaction.
Conclusions:
- The developed ternary supramolecular assembly is a promising dual-targeted agent for cancer therapy and imaging.
- This approach enhances the photodynamic therapeutic effect and enables precise visualization of cancer cells and lysosomes.
- Supramolecular chemistry provides an effective strategy for designing advanced nanomedicines for oncology.
