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Can Significant Coronary Artery Disease Coexist With Transient Takotsubo Cardiomyopathy, and How Does Spasm

Paolo Angelini1, Carlo Uribe1, Philip A Salem2

  • 1Center for Clinical Research, Texas Heart Institute, Houston, Texas.

Texas Heart Institute Journal
|March 30, 2023
PubMed

Insights

Metastatic breast cancer treatment led to chest pain and ST-segment elevation in an 86-year-old woman. Sublingual nitroglycerin resolved coronary artery spasm and takotsubo cardiomyopathy, suggesting chemotherapy may induce these cardiac events.

Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Metastatic breast cancer patients undergoing chemotherapy are at risk for cardiac complications.
  • Chemotherapy-induced endothelial dysfunction can increase coronary artery spasticity.

Keywords:
Coronary artery diseasecancerchemotherapycoronary stenosisnitroglycerinspasmtakotsubo cardiomyopathy

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