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Updated: Aug 4, 2025

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
Gate-voltage-modulated electrostatic interaction between the probe and the channel material of FET biosensors for
Hongyuan Zhang1, Zhi Zheng1, Zhicheng Zhang1
1State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China. zhengzhi@cug.edu.cn.
Abstract:
A gate-voltage-modulated strategy was proposed to improve the detection performance of telomerase. We comprehensively investigated the mechanism for the gate-voltage-modulated detection performance by modulating the electrostatic interaction between charges of a single-stranded DNA probe and electrons of the In2O3 channel. This gate-voltage-modulated interaction between the probe and the channel can potentially serve as a universal strategy for high-performance FET biosensors.
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