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Updated: Aug 3, 2025

Crystallization and Structural Determination of an Enzyme:Substrate Complex by Serial Crystallography in a Versatile Microfluidic Chip

Crystallization and Structural Determination of an Enzyme:Substrate Complex by Serial Crystallography in a Versatile Microfluidic Chip

Published on: March 20, 2021

SDU - software for high-throughput automated data collection at the Swiss Light Source.

Kate Mary Louise Smith¹, Ezequiel Panepucci¹, Jakub Wojciech Kaminski¹

¹Swiss Light Source, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.

Journal of Synchrotron Radiation

|April 12, 2023

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This summary is machine-generated.

Automated data collection at the Swiss Light Source is now possible with new software and hardware. This system enables unattended experiments, improving efficiency for macromolecular crystallography research.

Area of Science:

Crystallography
Structural Biology
Synchrotron Science

Background:

Advancements in automation are enabling unattended data collection at synchrotron facilities.
The Swiss Light Source (SLS) has upgraded its macromolecular crystallography (MX) beamlines with high-throughput sample changers and a new screening pipeline.

Purpose of the Study:

To report the implementation of automated data collection at the SLS.
To detail the software and hardware upgrades facilitating unattended operation.

Main Methods:

Upgraded the DA+ microservice software stack.
Implemented an automatic loop-centering service.
Deployed the Smart Digital User (SDU) software for autonomous control.

Main Results:

Keywords:

beamline automation data acquisition software high throughput loop centering protein crystallography

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Last Updated: Aug 3, 2025

Crystallization and Structural Determination of an Enzyme:Substrate Complex by Serial Crystallography in a Versatile Microfluidic Chip

Crystallization and Structural Determination of an Enzyme:Substrate Complex by Serial Crystallography in a Versatile Microfluidic Chip

Published on: March 20, 2021

The SDU software successfully manages communication, safety, centering, and alignment for data collection.
The integrated system allows for unattended data acquisition on MX beamlines.

Conclusions:

The developed automated system at SLS enhances experimental efficiency and throughput.
This advancement supports broader accessibility to synchrotron-based structural biology research.