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Vandetanib

Ahmed I Al-Ghusn¹, Ahmed H Bakheit², Mohamed W Attwa¹

¹Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 15, 2023

Summary

Vandetanib is an FDA-approved anti-cancer drug for medullary thyroid carcinoma. This review covers its properties, applications, synthesis, and analytical methods for accurate measurement.

Area of Science:

Pharmacology
Oncology
Analytical Chemistry

Background:

Vandetanib is an antineoplastic kinase inhibitor approved by the FDA in 2011.
It treats adults with specific types of medullary thyroid carcinoma.
Contraindicated in patients with serious cardiac conditions due to Q-T interval prolongation risk.

Purpose of the Study:

To provide a comprehensive overview of Vandetanib.
To detail its physical, molecular, and pharmacological properties.
To summarize synthesis, analytical measurement techniques, and characterization of raw materials.

Main Methods:

Literature review of Vandetanib's properties, action, and pharmacokinetics.
Compilation of reported Vandetanib measurement techniques.
Summary of synthesis and characterization methods.

Main Results:

Vandetanib's mechanism of action as a kinase inhibitor.
Established applications in medullary thyroid carcinoma treatment.
Overview of various analytical techniques for Vandetanib quantification.
Details on synthesis pathways and raw material characterization.

Conclusions:

Vandetanib is a key therapeutic agent for medullary thyroid carcinoma.
Understanding its analytical methods is crucial for routine analysis.
Comprehensive knowledge of its synthesis and properties aids in drug development and quality control.

Keywords:

An antineoplastic kinase inhibitor Anti-cancer drug Enantiomeric High-performance liquid chromatography Nonresectable Pharmacokinetics Vandetanib

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