Hemolysis performance analysis and a novel estimation model of roller pump system

Area of Science:

• Biomedical Engineering
• Fluid Dynamics
• Medical Devices

Background:

• Hemolysis performance is critical for roller pumps in life support systems.
• Evaluating hemolysis accurately is essential for device safety and efficacy.

Purpose of the Study:

• To develop and validate an estimation formulation for assessing hemolysis in roller pumps.
• To identify key factors influencing hemolysis performance.

Main Methods:

• Computational Fluid Dynamics (CFD) simulations were used to model roller pump performance.
• Hemolysis was calculated using the power law model and a novel estimation model based on geometric parameters.
• Simulation results were validated against in vitro experimental data.

Main Results:

• Rotary speed was the most significant factor affecting hemolysis, followed by roller number and tube diameter.
• The proposed estimation model achieved a lower relative error (4.93%) compared to the power law model (6.78%).
• Index of Hemolysis (IH) ranged from 8.73E-7 to 8.07E-5 at 20-100 rpm.

Conclusions:

• A significant, nonlinear relationship exists between IH and rotary speed.
• Larger tube diameters reduce hemolysis at constant flow rates, while multiple rollers negatively impact performance.
• The developed estimation formula provides a convenient and accurate method for predicting roller pump hemolysis.