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Updated: Aug 2, 2025

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Periarticular Injection in Total Knee Arthroplasty.
Andrew Schwartz1, Niall H Cochrane, William A Jiranek
1From the Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC (Schwartz, Cochrane, Jiranek, and Ryan), and the Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA (Schwartz).
Periarticular injections (PAIs) help manage pain after total knee arthroplasty (TKA), potentially speeding recovery and improving patient satisfaction. This study examines PAI variations to establish best practices for TKA pain control.
Area of Science:
- Orthopedic Surgery
- Anesthesiology
- Pain Management
Background:
- Effective pain management is crucial for total knee arthroplasty (TKA) recovery.
- Periarticular injections (PAIs) are increasingly utilized for postoperative pain control following TKA.
- Current practices for PAIs lack standardization, particularly when combined with nerve blocks.
Purpose of the Study:
- To evaluate the diverse ingredients and administration techniques of PAIs in TKA.
- To assess the outcomes associated with different PAI protocols in TKA patients.
- To identify potential areas for standardizing PAI use in TKA.
Main Methods:
- Systematic review of existing literature on PAIs for TKA.
- Analysis of PAI composition, dosage, and injection sites.
- Comparison of patient-reported pain scores and recovery metrics based on PAI protocols.
Main Results:
- Significant variability observed in PAI formulations and delivery methods across studies.
- PAIs demonstrate a trend towards reduced postoperative pain and shorter hospital stays.
- Adjuvant peripheral nerve blocks may influence PAI efficacy, requiring further investigation.
Conclusions:
- Standardization of PAI ingredients and techniques is needed for optimal TKA pain management.
- Further research should focus on defining the most effective PAI combinations and administration strategies.
- Optimized PAIs can enhance recovery and patient satisfaction after total knee arthroplasty.
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