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Updated: Aug 2, 2025
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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
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Interaction of Intestinal Microbiota with Medications
Mengchen Liu1, Jiaqiang Xu2, Qianna Jin3
1Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Current Drug Metabolism
|April 19, 2023
Summary
Individual drug responses vary due to gut microbes influencing drug metabolism. This review explores the gut microbiome
Area of Science:
- Microbiology
- Pharmacology
- Gastroenterology
Background:
- Individual drug response and metabolism differ significantly due to variations in gut microbiota composition.
- Gut microbes can impact drug absorption, distribution, metabolism, and excretion (ADME), and conversely, drugs can alter gut microbiome structure and function.
- Existing research often overlooks the clinical relevance of gut microbiome-drug interactions, particularly in conditions like irritable bowel syndrome (IBS).
Purpose of the Study:
- To review the intricate relationship between gut microbiome differences and drug metabolism.
- To highlight the implications for medical therapy and drug development in irritable bowel syndrome (IBS).
Main Methods:
- Literature review synthesizing current research on gut microbiome and drug metabolism.
- Focus on studies relevant to irritable bowel syndrome (IBS) indications.
Main Results:
- The human intestinal microbiota significantly influences the ADME processes of orally administered drugs.
- Gut microbes, via various enzymes, can modify drug efficacy and toxicity.
- Medications can reciprocally alter the composition and function of the intestinal microbiota.
Conclusions:
- Understanding the gut microbiome's role in drug metabolism is crucial for personalized medicine, especially in IBS.
- Further elucidation of gut microbiota-drug interactions is needed for improved therapeutic strategies and drug development.
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